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KMID : 0386520120200020001
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Research Institute of Korean Medicone
2012 Volume.20 No. 2 p.1 ~ p.16
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Study on the modulation of immune system of CPS in atopic dermatitis induced animal models
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Lee Youn-Jeong
Gim Seon-Bin
Choi Hak-Joo
Lee Ki-Moo
Kim Dong-Hee
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Abstract
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In order to study the effect of CPS in the treatment of atopic dermatitis (AD), its role on various immune related cytokines were tested. Levels of liver and kidney function markers such as ALT, AST, BUN in NC/Nga mice were all normal indicating no toxicity in CPS treated group. Significant recovery from AD could be observed in CPS treated group through naked eye observation. Dermatitis index was significantly decreased after 11, 12, and 13 weeks of treatment. CD4+, CD8+, CD3+ /CD69+ immune cell ratio in DLN were decreased significantly by 37.2%, 49%, 20.8% in CPS treated group. CD4+ and CD11b+ /Gr-1+ immune cell ratio in dorsal skin were decreased significantly by 50.8% and 59.2% in CPS treated group. Expression of IL-4, IL-5, IL-6, IL-13 and TNF- in spleen were decreased by 78.8%, 97.8%, 64.7%, 73.6%, and 68.4%, respectively in CPS treated group. The results above strongly indicated the significant immune modulatory effect of CPS and thus clinical application of CPS on AD treatment.
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KEYWORD
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CPS(chunggipadoksan), atopic dermatitis, immune cell, cytokine
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